To provide an enteric coated preparation resistant to dissolution in the stomach and dissolving in the intestines to develop physiological effect by orally administrating a physiologically active substance, and a method for the production of the preparation and especially to provide a formed article leaving the activity, or the like, when using as a tablet, or the like, by a compression forming method.

The enteric coated preparation is produced by (I) coating a core material A with an oil-and-fat layer B having a melting point of ≥40°C, (II) compounding the oil-and-fat substance with a vehicle C and contacting the product with a water-containing alcohol solution containing a protein D soluble in the water-containing alcohol to form a granule, and (III) coating the granule with an oil-and-fat layer E having a melting point of ≥40°C.