PURPOSE: To provide an enteric granulated agent having smooth surface to enable easy administration, resistant to dissolution in gastric juice after oral administration, dissolving in the digestive juice in intestines and, accordingly, free from the influence of gastric juice, exhibiting the physiological activity in the enteric canal and storable over a long period without lowering the activity.

CONSTITUTION: A physiologically active substance having high availability in the living body (especially in the enteric canal) and susceptible to gastric juice (e.g. lactobacillus and bifidus bacteria) is used as a substance to be granulated. The substance is coated with (A) a layer containing oil and fat and a diluting agent and stable to long-term storage and (B) a layer containing a protein (preferably zein) soluble in a hydrated alcohol and stable in low pH region. The coated substance is further coated with (C) a sugar coating layer containing a sugar such as granulated sugar to obtain the objective enteric granule composed of multiple granules easily swallowable in oral administration and having the above effects. The layer C is preferably incorporated with functional substances such as a mouth refreshing gent, a mouth odor eliminating agent and vitamin C. The order of the layers A and B may be reversed or the layers A and B may be alternately applied to form a multilayer granule.