Title:
EPITOPE FOR MEDICAL TREATMENT AND USE FOR THE SAME
Document Type and Number:
Japanese Patent JP2016122016
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To develop a test to be used for diagnosis of Celiac disease in an initial stage.SOLUTION: Disclosed is a method for diagnosing Celiac disease or susceptibility to Celiac disease in a sample obtained from an individual including; bringing a sample from an individual into contact with at least one agent selected from (i) a peptide containing at least one epitope having a sequence selected from a group comprising sequence numbers: 18, 20-22, 31-36, 40-44, and 46 and their equivalents, (ii) an analogue of (i) which is recognized by a T cell receptor that recognizes (i), and which is not more than 50 amino acids in length, and (iii) a peptide comprising at least one epitope having a sequence selected from a sequence number: 1 and a sequence number: 2 in addition to an agent arbitrarily selected from (i) and (ii); and determining in vitro whether or not T cells in the sample recognize the agent, where recognition by the T cells indicates that the individual has or is susceptible to Celiac disease.SELECTED DRAWING: None
Inventors:
ANDERSON ROBERT PAUL
ADRIAN VIVIAN SIMTON HILL
JEWELL DEREK PARRY
ADRIAN VIVIAN SIMTON HILL
JEWELL DEREK PARRY
Application Number:
JP2016037111A
Publication Date:
July 07, 2016
Filing Date:
February 29, 2016
Export Citation:
Assignee:
ISIS INNOVATION
International Classes:
G01N33/53; A01K67/027; A61K38/00; A61K45/00; A61P1/04; A61P37/00; A61P43/00; C07K14/415; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/02
Foreign References:
| WO2001025793A2 | 2001-04-12 |
Other References:
VADER L W, JOURNAL OF EXPERIMENTAL MEDICINE, vol. V195 N5, JPN5004017564, 4 March 2002 (2002-03-04), JP, pages 43 - 649
PIPER JUSTIN L, BIOCHEMISTRY, vol. V41 N1, JPN5004017561, 8 January 2002 (2002-01-08), pages 86 - 393
BIOLOGICALS, vol. 29, JPN6015012909, 2001, pages 179-81
PIPER JUSTIN L, BIOCHEMISTRY, vol. V41 N1, JPN5004017561, 8 January 2002 (2002-01-08), pages 86 - 393
BIOLOGICALS, vol. 29, JPN6015012909, 2001, pages 179-81
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu