Title:
エストロゲン受容体調節剤
Document Type and Number:
Japanese Patent JP2007512344
Kind Code:
A
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.
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Inventors:
Blizzard, Timothy A
Goode, Kyandeade
Morgan, Jerry Day, The Second
Goode, Kyandeade
Morgan, Jerry Day, The Second
Application Number:
JP2006541415A
Publication Date:
May 17, 2007
Filing Date:
November 19, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07J1/00; A61K31/56; A61K31/568; A61K31/57; A61K31/59; A61K31/663; A61K38/23; A61K45/00; A61P1/02; A61P1/04; A61P3/04; A61P3/06; A61P5/30; A61P5/32; A61P9/00; A61P9/10; A61P9/12; A61P13/02; A61P13/08; A61P15/00; A61P15/10; A61P17/00; A61P19/08; A61P19/10; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07J7/00; C07J41/00
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura