Title:
新規分子機能の進化
Document Type and Number:
Japanese Patent JP4384229
Kind Code:
B2
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogues to the amplification of natural biopolymer such as polynucleotides and protein.
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Inventors:
David Earl. Riu
Zev J. Gartner
Matthew W. Canaan
Zev J. Gartner
Matthew W. Canaan
Application Number:
JP2008042250A
Publication Date:
December 16, 2009
Filing Date:
February 22, 2008
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C08G85/00; C12N15/09; C07B61/00; C12N15/10; C12P1/00; C12P19/34; C12P21/00; C40B40/04; C40B50/04; C40B50/18; C40B70/00; C40B80/00
Foreign References:
| WO2002074929A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita