Title:
(+)-エキソ-6-フェニル-3-アザビシクロ-[3.2.0]ヘプタンの製造方法
Document Type and Number:
Japanese Patent JP3842044
Kind Code:
B2
Abstract:
A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.
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Inventors:
Norbert Bischoff
Ernst Bushman
Michael Henningsen
Georg Arnold Cry
Liner munshauer
Thomas Pfeiffer
Gerd Steiner
Wolfgang Feer Guts
Ernst Bushman
Michael Henningsen
Georg Arnold Cry
Liner munshauer
Thomas Pfeiffer
Gerd Steiner
Wolfgang Feer Guts
Application Number:
JP2000577151A
Publication Date:
November 08, 2006
Filing Date:
October 13, 1999
Export Citation:
Assignee:
Abbott GmbH & Co. KG
International Classes:
C07D209/52; A61K31/40; C07B37/10; C07B57/00; C07D
Domestic Patent References:
| JP7507771A | ||||
| JP7508011A | ||||
| JP7508012A |
Other References:
Heterocycles,(1995),40(1),p.319-330
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel