Title:
新規な置換グリシン誘導のＦＸＩＡ阻害剤
Document Type and Number:
Japanese Patent JP6785838
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I): [INSERT CHEMICAL STRUCTURE HERE] (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Inventors:
James Earl Court
William Earl Ewing
Donald Jay P. Pinto
Leon M Smith the Second
William Earl Ewing
Donald Jay P. Pinto
Leon M Smith the Second
Application Number:
JP2018505695A
Publication Date:
November 18, 2020
Filing Date:
August 03, 2016
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D211/86; A61K31/4418; A61K31/4439; A61K31/50; A61K31/513; A61K31/517; A61K31/519; A61K31/5377; A61K31/5383; A61K31/541; A61K31/551; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P27/02; A61P35/00; A61P43/00; C07D237/14; C07D401/02; C07D401/06; C07D401/14; C07D403/02; C07D403/14; C07D407/14; C07D409/14; C07D413/14; C07D417/14; C07D451/04; C07D471/04; C07D471/10; C07D487/04; C07D498/04
Domestic Patent References:
| JP57501328A |
Foreign References:
| DE2318807A | ||||
| WO2014022767A1 | ||||
| WO2014160592A1 |
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro