Title:
Film evaporation for generating the protein-therapeutics medicine of high concentration
Document Type and Number:
Japanese Patent JP6159528
Kind Code:
B2
Abstract:
The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltration methods, e.g., protein solution concentrations of greater than about 260 grams of protein per liter of solution.
Inventors:
Glen Reid Bolton
Hari Acharya
Austin wayne boche
Hari Acharya
Austin wayne boche
Application Number:
JP2012502203A
Publication Date:
July 05, 2017
Filing Date:
March 24, 2010
Export Citation:
Assignee:
Weiss LRC
International Classes:
C07K1/34; A61K38/00; A61K39/395; B01D61/14; B01D63/02; B01D63/08; B01D63/10
Domestic Patent References:
| JP10501733A | ||||
| JP2005530845A | ||||
| JP11512753A | ||||
| JP2008512473A |
Other References:
特許庁,1-6-1 膜材質,平成17年度 標準技術集 水処理技術 [online],2006年 5月12日,p.72-73,[retrieved on 2015.05.19], Retrieved from the Internet,URL,http://www.jpo.go.jp/shiryou/s_sonota/hyoujun_gijutsu/mizushori/1-6-1.pdf
Journal of Membrane Science,2005年 3月11日,Vol.252, No.1-2,p.19-28
Journal of Membrane Science,2005年 3月11日,Vol.252, No.1-2,p.19-28
Attorney, Agent or Firm:
Noh four
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