Title:
改良された補体結合を有する高次多量体化免疫グロブリンＦＣ組成物を作製するためのヒトタンパク質断片の融合タンパク質
Document Type and Number:
Japanese Patent JP7122440
Kind Code:
B2
Abstract:
The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves stradomers that increase multimerization and bind preferentially to complement and that are useful in the treatment and prevention of disease.
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Inventors:
Brock, David Es.
olsen, henrik
olsen, henrik
Application Number:
JP2021106156A
Publication Date:
August 19, 2022
Filing Date:
June 25, 2021
Export Citation:
Assignee:
Glicknick Inc.
International Classes:
C07K19/00; A61K39/395; A61P5/00; A61P7/00; A61P7/06; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P17/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/04; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P37/06; A61P37/08; A61P43/00; C07K16/00; C12N15/13
Domestic Patent References:
| JP2013543483A |
Foreign References:
| WO2011091078A2 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
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