GALENIC FORMULA WITH EXTENDED RELEASE OF MILNACIPRAN

Title:

GALENIC FORMULA WITH EXTENDED RELEASE OF MILNACIPRAN

Document Type and Number:

Japanese Patent JP2010163447

Kind Code:

A

Abstract:

To provide a prolonged release galenic formula having a multi-particulate form containing a plurality of microgranules and enabling oral administration of milnacipran in a single daily dose of 60-140 mg.

The prolonged release galenic formula includes active microgranules containing a saccharose and/or starch nucleus of a particle diameter of 200-2,000 μm and containing in each microgranule a binder and 150-1,000 μg of milnacipran, wherein each microgranule is coated with a 20-100 μm-thick film derived from at least one polymer insoluble in water but permeable to physiological liquids, and the galenic formula enables an in vitro release corresponding to the following pattern: between 10 and 55% of the dose released in 2 hours, between 40 and 75% of the dose released in 4 hours, between 70 and 90% of the dose released in 8 hours, and between 80 and 100% of the dose released in 12 hours.

Inventors:

PAILLARD BRUNO
GOUTAY ERIC
AVAN JEAN-LOUIS
BOUGARET JOEL

Application Number:

JP2010053612A

Publication Date:

July 29, 2010

Filing Date:

March 10, 2010

Export Citation:

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Assignee:

PF MEDICAMENT

International Classes:

A61K31/165; A61K9/16; A61K9/50; A61K9/52; A61K47/02; A61K47/10; A61K47/14; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61P25/24

Domestic Patent References:

JPH032114A	1991-01-08
JPH083035A	1996-01-09

Attorney, Agent or Firm:

Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito

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