To provide a method useful for imparting tamper-proof property to a transdermal dosage form comprising opioid or pharmaceutically acceptable salts thereof.
The method comprises introduction of both of a free base of an opioid antagonist, and a pharmaceutically acceptable salt of an opioid antagonist, into the transdermal dosage form comprising opioid or a pharmaceutically acceptable salt thereof. The preferable amount of the opioid or the pharmaceutically acceptable salt thereof is 0.1 to 500 mg, and the weight ratio of the opioid or the pharmaceutically acceptable salt thereof with the total of the free base form of the opioid antagonist and the pharmaceutically acceptable salt of the opioid antagonist is 15:1 to 1:5. The preferable opioid is such as oxycodone, hydrocodone, buprenorphine, fentanyl, etc., and the preferable opioid antagonist is such as naltrexone, naloxone, nalmefene, etc.
COPYRIGHT: (C)2010,JPO&INPIT
REIDENBERG BRUCE
| JPH04501412A | 1992-03-12 | |||
| JP2001526228A | 2001-12-18 | |||
| JP2001526229A | 2001-12-18 |
Eiji Katayama
Junko Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
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