Title:
GAMMA-1 AND GAMMA-3 ANTI-HUMAN CD23 MONOCLONAL ANTIBODY AND USE THEREOF AS THERAPEUTIC AGENT
Document Type and Number:
Japanese Patent JP2010095526
Kind Code:
A
Abstract:
To produce a new ligand (antibody) specific to CD23.
Monoclonal antibodies specifically binding human CD23 (FceRII/CD23) which is a low affinity receptor for IgE and containing either a human 1 or human 3 constant domain are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Therefore, they are practically useful for treating or preventing disease conditions wherein inhibition of induced IgE production is therapeutically desirable, e.g. allergic conditions, autoimmune diseases and inflammatory diseases.
Inventors:
REFF MITCHELL E
KLOETZER WILLIAM S
NAKAMURA TAKEHIKO
KLOETZER WILLIAM S
NAKAMURA TAKEHIKO
Application Number:
JP2009276687A
Publication Date:
April 30, 2010
Filing Date:
December 04, 2009
Export Citation:
Assignee:
BIOGEN IDEC INC
International Classes:
C07K16/28; C12N15/02; A61K39/395; A61P29/00; A61P37/00; A61P37/02; A61P37/08; A61P43/00; C12N15/09; C12P21/08; A61K38/00; C07K
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Tsutomu Toyama
Hidemi Matsukura
Tsutomu Toyama