PHOSPHODIESTERASE ACTIVITY AND REGULATION OF PHOSPHODIESTERASE 1B-MEDIATED SIGNALING IN BRAIN

Japanese Patent JP2010095525

A

To provide a screening method usable for development of a new composition or medicine, usable for treatment of disease or injury in relation to regulation of phosphodiesterase in a nervous system, and to provide a treatment agent of disease or injury due to abnormality or regulation injury of an intracellular signaling pathway to be modulated by phosphodiesterase at least in a certain degree.

The medicine increases activity of a dopamine D1 intracellular signaling pathway in a cell or tissue expressing a dopamine D1 intracellular receptor, wherein the medicine includes, as an effective component, a compound which reduces PDE1B-mediated cAMP hydrolysis in order to increase activity of the dopamine D1 receptor, resulting from combining with PDE1B or changing its expression.

GREENGARD PAUL
REPASKE DAVID
SNYDER GRETCHEN

JP2009260695A

April 30, 2010

November 16, 2009

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UNIV ROCKEFELLER
CHILDRENS HOSP MEDICAL CENTER

A61K45/00; A61K38/17; G01N33/50; A61P1/08; A61P9/10; A61P9/12; A61P15/00; A61P15/08; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P35/00; A61P43/00; C12N15/09; C12Q1/02; C12Q1/44; G01N33/15; G01N33/94

JPH1143499A	1999-02-16
JP2000224992A	2000-08-15

WO2001046145A1	2001-06-28
WO2000017345A1	2000-03-30
GB2151629B	1986-01-02
WO1997035989A2	1997-10-02
WO2001000851A1	2001-01-04

JPN6008055824; ＢＲＡＩＮ　ＲＥＳＥＡＲＣＨ　ＢＵＬＬＥＴＩＮ ＶＯＬ．５３，　ＮＯ．３, 2000, Ｐ．２４５-２５４
JPN6008055826; ＰＲＯＣ　ＮＡＴＬ　ＡＣＡＤ　ＳＣＩ　ＵＳＡ ＶＯＬ．９０, 1993, Ｐ．３４６２-３４６５
JPN6008055825; Ｊ　ＮＥＵＲＯＳＣＩ ＶＯＬ．１４，　ＮＯ．３, 1994, Ｐ．１２５１-１２６１

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Masayuki Nakagawa
Yasushi Ochiai

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