Title:
グリコゲンシンターゼキナーゼ3のインヒビター
Document Type and Number:
Japanese Patent JP2004514656
Kind Code:
A
Abstract:
New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
Inventors:
Eggplant, John M.
Harrison, Stephen Dee.
Ring, David Bee.
Voice, Rasta S.
Johnson, Kirk
Pfister, Keith Bee.
La Mercy, Savi Suri
Sealy, Lynn
Wagman, Alain Es.
Desai, Manoji
Levine, Barry H.
Harrison, Stephen Dee.
Ring, David Bee.
Voice, Rasta S.
Johnson, Kirk
Pfister, Keith Bee.
La Mercy, Savi Suri
Sealy, Lynn
Wagman, Alain Es.
Desai, Manoji
Levine, Barry H.
Application Number:
JP2002525117A
Publication Date:
May 20, 2004
Filing Date:
September 06, 2001
Export Citation:
Assignee:
Chiron Corporation
International Classes:
C12N9/99; A61K31/444; A61K31/496; A61K31/505; A61K31/506; A61K31/519; A61K31/5377; A61P3/04; A61P3/10; A61P9/10; A61P9/12; A61P15/00; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P35/00; A61P37/04; A61P43/00; C07D213/64; C07D213/74; C07D213/75; C07D213/80; C07D213/85; C07D231/12; C07D233/60; C07D235/06; C07D239/42; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D487/04; C12N1/38; (IPC1-7): C07D213/74; A61K31/444; A61K31/496; A61K31/505; A61K31/506; A61K31/519; A61K31/5377; A61P3/04; A61P3/10; A61P9/10; A61P9/12; A61P15/00; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P35/00; A61P37/04; A61P43/00; C07D213/75; C07D213/80; C07D213/85; C07D233/60; C07D235/06; C07D239/42; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D487/04; C12N1/38; C12N9/99
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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