Title:
GLYCOPOLYSIALYLATION OF NON-BLOOD COAGULATION PROTEIN
Document Type and Number:
Japanese Patent JP2018024882
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a material and a method for conjugating a water-soluble polymer with a carbohydrate-containing compound other than a blood coagulation protein, improving pharmacodynamic and/or pharmacokinetic properties of the compound while minimizing cost related to various agents.SOLUTION: There is disclosed a method for conjugating polysialic acid (PSA) or modified PSA (mPSA) to an oxidized carbohydrate part of a DNA decomposition enzyme by using a hydrazide linker. Further there is disclosed a method for conjugating polysialic acid (PSA) or modified PSA (mPSA) to (1) glycoprotein other than blood coagulation protein, (2) ganglioside or (3) an oxidized carbohydrate part of a drug delivery system containing a carbohydrate group.SELECTED DRAWING: None
Inventors:
JAIN SANJAY
GREGORIADIS GREGORY
ARCHANA DWIVEDI
SRIJIT NATH
JUERGEN SIEKMANN
STEFAN HAIDER
HANSPETER ROTTENSTEINER
PETER TURECEK
GREGORIADIS GREGORY
ARCHANA DWIVEDI
SRIJIT NATH
JUERGEN SIEKMANN
STEFAN HAIDER
HANSPETER ROTTENSTEINER
PETER TURECEK
Application Number:
JP2017171508A
Publication Date:
February 15, 2018
Filing Date:
September 06, 2017
Export Citation:
Assignee:
LIPOXEN TECH LTD
BAXTER INC
BAXTER GMBH
BAXTER INC
BAXTER GMBH
International Classes:
C08B37/00; A61K38/02; A61K38/16; A61K38/17; A61K38/18; A61K38/19; A61K38/22; A61K38/24; A61K38/28; A61K38/30; A61K38/46; A61K39/395; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61K47/60; A61K47/61; A61K47/69; A61P3/10; A61P5/14; A61P5/24; A61P7/00; A61P13/00; A61P15/00; A61P35/00; A61P37/02; A61P43/00; C07H7/027; C07H15/10; C07K1/113; C07K2/00
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VACCINE, vol. 24, JPN6014037779, 2006, pages 716 - 729, ISSN: 0004070205
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Attorney, Agent or Firm:
Takuya Shindo