HETEROCYCLIDENE DERIVATIVE HAVING p-SUBSTITUTED ARYLACETAMIDE

Japanese Patent JP2011201778

A

To provide a compound that modulates the function of TRPV1 receptor, a TRPV1 receptor modulator comprising the derivative as an active ingredient, and an agent for preventing or treating a disease involving TRPV1 receptor, such as pain.

The compound represented by formula (I) (wherein m represents a number of 0 to 2; n represents a number of 1 or 2; p represents a number of 0 to 2; q represents a number of 0 or 1; R1, R2 and R3 each represents halogen or the like; X1 represents O or -NR6-; X2 represents methylene, O or -NH-; G1 and G2 each represents N or C-R7; and the moiety represented by Cycle represents a 5 to 6-membered aryl or the like), a salt thereof or a solvate thereof are provided. A pharmaceutical composition comprising the same as an active ingredient is also provided.

MATSUNAGA ATSUO
UCHIDA HIDEHARU
MAEDA NORITAKA

JP2008190346A

October 13, 2011

July 23, 2008

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MOCHIDA PHARM CO LTD

C07D313/08; A61K31/335; A61K31/35; A61K31/353; A61K31/382; A61K31/397; A61K31/4025; A61K31/4523; A61K31/453; A61K31/47; A61K31/4709; A61K31/506; A61K31/536; A61K31/553; A61P21/00; A61P25/04; A61P29/00; A61P43/00; C07D215/14; C07D265/34; C07D267/14; C07D311/58; C07D335/06; C07D337/08; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D491/052; C07D493/04

Calyx
Miyazaki Yoshio
Tsutomu Kato
Kyoko Oyama
Kaoru Onozuka
Akio Tagami
High Masahiro
Norio Mori
Seiji Yamada

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