Title:
HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
Document Type and Number:
Japanese Patent JP2019151650
Kind Code:
A
Abstract:
To provide compounds for treating viral infections such as hepatitis B, the compounds having allosteric effector properties against hepatitis B virus core protein (Cp) thereby capable of generating defective capsids in viruses.SOLUTION: The invention provides, e.g., the compound represented by the formula 1224 in the figure.SELECTED DRAWING: None
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Inventors:
WILLIAM W TURNER JR
LEE DANIEL ARNOLD
HANS MAAG
ADAM ZLOTNICK
LEE DANIEL ARNOLD
HANS MAAG
ADAM ZLOTNICK
Application Number:
JP2019085742A
Publication Date:
September 12, 2019
Filing Date:
April 26, 2019
Export Citation:
Assignee:
INDIANA UNIV RESEARCH AND TECH CORP
ASSEMBLY BIOSCIENCES INC
ASSEMBLY BIOSCIENCES INC
International Classes:
C07D223/20; A61K31/5513; A61K31/553; A61K31/554; A61K45/00; A61P1/16; A61P31/20; A61P43/00; C07D243/38; C07D281/16; C07D401/12; C07D403/12; C07D413/12; C07D417/12; C07D417/14; C07D513/04
Domestic Patent References:
| JP2007527412A | 2007-09-27 | |||
| JPS462510B1 | ||||
| JP2011529053A | 2011-12-01 | |||
| JPH06506930A | 1994-08-04 |
Foreign References:
| US20070105835A1 | 2007-05-10 | |||
| WO2011075607A1 | 2011-06-23 | |||
| WO2013006394A1 | 2013-01-10 | |||
| GB1480553A | 1977-07-20 | |||
| US20070105819A1 | 2007-05-10 |
Other References:
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. Vol.357(3), JPN6021010001, 2007, pages 596 - 602, ISSN: 0004469906
CHEMISTRY & BIOLOGY, vol. 13, JPN6021010002, 2006, pages 765 - 770, ISSN: 0004469907
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PLOS ONE, vol. Vol.7 Iss.11 e49075, JPN6018042123, 2012, pages 1 - 8, ISSN: 0004469909
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. Vol.357(3), JPN6021010001, 2007, pages 596 - 602, ISSN: 0004469906
CHEMISTRY & BIOLOGY, vol. 13, JPN6021010002, 2006, pages 765 - 770, ISSN: 0004469907
薬学雑誌, vol. Vol.89(2), JPN6021010003, 1969, pages 158 - 163, ISSN: 0004469908
PLOS ONE, vol. Vol.7 Iss.11 e49075, JPN6018042123, 2012, pages 1 - 8, ISSN: 0004469909
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki
Norio Omori
Yasuhito Suzuki