Title:
HETEROARYL AS PI3K INHIBITOR AND USE THEREOF
Document Type and Number:
Japanese Patent JP2015147804
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a novel PI3K inhibitor having good therapeutic properties (especially therapeutic properties favorable for treating proliferative disorder, inflammatory disorder or cardiovascular disorder).SOLUTION: The invention provides a compound of the formula (IA) or (IB), where R, R, Gand HY are as described in the specification. The compound is an inhibitor of PI3K and/or mTor and therefore useful for treating proliferative disorder, inflammatory disorder or cardiovascular disorder. The invention provides a compound useful as an inhibitor of PI3K enzyme and therefore the compound is useful for treatment of proliferative disorder, inflammatory disorder or cardiovascular disorder such as tumors and/or growth of tumor cells mediated by PI3K.
More Like This:
Inventors:
SAKANO HIROSHI
HIROSE MASAAKI
KURASAWA OSAMU
STEVEN P LANGSTON
MIZUTANI HIROTAKE
SHI ZHAN
IRACHE VISIERS
VOS TRICIA J
STEPAN VYSKOCIL
HIROSE MASAAKI
KURASAWA OSAMU
STEVEN P LANGSTON
MIZUTANI HIROTAKE
SHI ZHAN
IRACHE VISIERS
VOS TRICIA J
STEPAN VYSKOCIL
Application Number:
JP2015101516A
Publication Date:
August 20, 2015
Filing Date:
May 19, 2015
Export Citation:
Assignee:
MILLENNIUM PHARM INC
International Classes:
C07D409/14; A61K31/429; A61K31/4365; A61K31/437; A61K31/4439; A61K31/444; A61K31/4545; A61K31/496; A61K31/5025; A61K31/506; A61K31/5377; A61P7/02; A61P9/00; A61P9/04; A61P9/12; A61P19/02; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D417/14; C07D471/04; C07D487/04; C07D495/04; C07D513/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita