Title:
ヘテロ二官能性ポリエチレングリコール誘導体およびその調製方法
Document Type and Number:
Japanese Patent JP4344110
Kind Code:
B2
Abstract:
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate polymer having a formula of W-Poly-OH is provided bearing a removable group W at one terminus. The intermediate polymer W-Poly-OH is first altered by modifying the OH group to a first functional group X, followed by the removal of W to generate a second hydroxyl group. The latter hydroxyl group may then be further converted to a second functional group Y, thus providing the desired heterobifunctional derivative.
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Inventors:
Bentley, Michael David
Harris, Jay Milton
Kozlowski, Antoni
Harris, Jay Milton
Kozlowski, Antoni
Application Number:
JP2001529753A
Publication Date:
October 14, 2009
Filing Date:
October 08, 1999
Export Citation:
Assignee:
Nectar Therapeutics AE, Corporation
International Classes:
C08G85/00; A61K47/48; C08G65/329
Domestic Patent References:
| JP7316285A | ||||
| JP7048450A | ||||
| JP8092366A |
Other References:
J.Milton Harris,POLY(ETHYLENE GLYCOL)CHEMISTRY,Plenum Publishing Corporation,1992年,347-369,376-381
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo