Title:
代謝調節型グルタミン酸受容体のヘテロ環式アセトフェノン増強剤
Document Type and Number:
Japanese Patent JP2008508288
Kind Code:
A
Abstract:
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
Inventors:
Pinkerton, Anthony Bee
Bernier, Jean-Mitzier
Kyube, Lowena Buoy
Hatsuchinson, Jiyoung H
Towan, Tohwa
Bonneuf, Celine
Gobatsk, Stephen Pee
Kamenetska, Theodore
Bernier, Jean-Mitzier
Kyube, Lowena Buoy
Hatsuchinson, Jiyoung H
Towan, Tohwa
Bonneuf, Celine
Gobatsk, Stephen Pee
Kamenetska, Theodore
Application Number:
JP2007523713A
Publication Date:
March 21, 2008
Filing Date:
July 26, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07C49/84; A61K31/12; A61K31/136; A61K31/166; A61K31/216; A61K31/235; A61K31/24; A61K31/277; A61K31/343; A61K31/352; A61K31/397; A61K31/404; A61K31/41; A61K31/416; A61K31/4164; A61K31/4184; A61K31/423; A61K31/4245; A61K31/427; A61K31/428; A61K31/4355; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/47; A61K31/472; A61K31/496; A61K31/505; A61K31/52; A61K31/66; A61P25/00; A61P25/06; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07C69/738; C07C69/94; C07C217/76; C07C229/60; C07C235/42; C07C255/54; C07C323/12; C07D205/04; C07D209/08; C07D213/30; C07D213/38; C07D213/63; C07D213/64; C07D213/65; C07D213/70; C07D213/71; C07D213/74; C07D213/84; C07D213/89; C07D215/20; C07D217/02; C07D217/04; C07D231/56; C07D233/60; C07D235/08; C07D235/10; C07D235/18; C07D235/28; C07D239/34; C07D239/42; C07D257/04; C07D263/58; C07D271/10; C07D277/20; C07D277/36; C07D307/80; C07D311/14; C07D311/16; C07D311/22; C07D311/58; C07D311/66; C07D401/04; C07D417/04; C07D471/04; C07D473/38
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura