Title:
老化-関連及び糖尿病性血管性合併症のための複素環式化合物
Document Type and Number:
Japanese Patent JP4485744
Kind Code:
B2
Abstract:
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
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Inventors:
Sankara Narayanan, Arangdi
Application Number:
JP2002583424A
Publication Date:
June 23, 2010
Filing Date:
April 02, 2002
Export Citation:
Assignee:
TORRENT PHARMACEUTICALS LIMITED
International Classes:
C07D401/04; A61K8/00; A61K8/49; A61K31/4427; A61K31/4436; A61K31/4439; A61K31/4545; A61K31/4709; A61P1/00; A61P1/16; A61P3/00; A61P9/10; A61P11/00; A61P13/12; A61P15/10; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P39/06; A61P43/00; A61Q17/04; A61Q19/00; A61Q19/08; C07D401/14; C07D405/14; C07D409/00; C07D409/04; C07D409/14; C07D411/04; C07D413/04; C07D413/14
Domestic Patent References:
| JP64022869A | ||||
| JP49031989B1 | ||||
| JP9291082A | ||||
| JP6049045A |
Foreign References:
| US5330994 | ||||
| US3501312 | ||||
| WO1998056785A1 | ||||
| US3957805 | ||||
| WO1999025690A1 | ||||
| WO2000051987A1 | ||||
| WO2001025208A1 | ||||
| WO2001025209A1 |
Other References:
Giard, Thierry,Pyrrolidines bearing a quaternary α-stereogenic center. Part 1. Synthesis of analogs of ABT-418, a powerful nicotinic agonist,Tetrahedron Letters,1999年,Vol.40,No.30,pp.5495-5497
Huffman, John W.,Substances related to the Iboga alkaloids. Synthesis and reactions of 3-(2-indolyl)piperidine,Journal of Organic Chemistry,1962年,Vol.27,pp.503-506
Wu, Feiyue,Preparation and Study of Tautomers Derived from 2-(2'-Pyridyl)indole and Related Compounds,Journal of Organic Chemistry,1998年,Vol.63,No.12,pp.4055-4061
Ferles, Miloslav,Studies in the pyridine series. LIV. Reaction of 1-pyridyl-1,3- butanediones and 1,3-dipyridyl-1,3-propanediones,Collection of Czechoslovak Chemical Communications,1981年,Vol.46,No.5,pp.1167-1172
Ram, Vishnu Ji,Ring transformation reactions. I. Conversion of 6-aryl-4-(methylthio)-2- oxo-2H-pyran-3-carbonitriles to pyrazoles,Liebigs Annalen der Chemie,1991年,No.11,pp.1229-1231
Belgodere, Elena,Heterocycles,Studies on isomeric pyridylisoxazoles,1983年,Vol.20,No.3,pp.501-504
Huffman, John W.,Substances related to the Iboga alkaloids. Synthesis and reactions of 3-(2-indolyl)piperidine,Journal of Organic Chemistry,1962年,Vol.27,pp.503-506
Wu, Feiyue,Preparation and Study of Tautomers Derived from 2-(2'-Pyridyl)indole and Related Compounds,Journal of Organic Chemistry,1998年,Vol.63,No.12,pp.4055-4061
Ferles, Miloslav,Studies in the pyridine series. LIV. Reaction of 1-pyridyl-1,3- butanediones and 1,3-dipyridyl-1,3-propanediones,Collection of Czechoslovak Chemical Communications,1981年,Vol.46,No.5,pp.1167-1172
Ram, Vishnu Ji,Ring transformation reactions. I. Conversion of 6-aryl-4-(methylthio)-2- oxo-2H-pyran-3-carbonitriles to pyrazoles,Liebigs Annalen der Chemie,1991年,No.11,pp.1229-1231
Belgodere, Elena,Heterocycles,Studies on isomeric pyridylisoxazoles,1983年,Vol.20,No.3,pp.501-504
Attorney, Agent or Firm:
Narumi Morishima