Title:
ヘキサマー４面体ＲＮＡナノ構造
Document Type and Number:
Japanese Patent JP7364194
Kind Code:
B2
Abstract:
Disclosed are nanostructures comprising a ribonucleic acid (RNA) scaffold comprising a hexameric tetrahedral core. The tetrahedral core may comprise four hexameric RNA nanorings linked together. Related pharmaceutical compositions, methods of modulating the expression of a target gene in a mammal, methods of treating or preventing a disease in a mammal, and methods of producing a hexameric tetrahedral RNA nanostructure are also disclosed.
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Inventors:
Shapiro, Bruce A.
Zakrevsky, Paul Jay.
Jaeger, backpack
Zakrevsky, Paul Jay.
Jaeger, backpack
Application Number:
JP2020563479A
Publication Date:
October 18, 2023
Filing Date:
May 08, 2019
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/10; A61K31/7105; A61P31/12; A61P35/00; C12N15/113
Foreign References:
| US20100016409 | ||||
| WO2017189870A1 | ||||
| WO2017197009A1 |
Other References:
Hui Li et al.,Advanced Materials,2016年09月14日,Vol. 28, Issue 34,pp. 7501-7507,DOI: 10.1002/adma.201601976
Daniel Jasinski et al.,ACS Nano,2017年01月03日,Vol. 11, No. 2,pp. 1142-1164,DOI: 10.1021/acsnano.6b05737
Daniel Jasinski et al.,ACS Nano,2017年01月03日,Vol. 11, No. 2,pp. 1142-1164,DOI: 10.1021/acsnano.6b05737
Attorney, Agent or Firm:
Hajime Takashima
Mitsuyoshi Kamada
Kyoko Doi
Yaeko Tamura
Hirofumi Taima
Atsuko Akai
Tomiya Tosaki
Tatsuya Seki
Mitsuyoshi Kamada
Kyoko Doi
Yaeko Tamura
Hirofumi Taima
Atsuko Akai
Tomiya Tosaki
Tatsuya Seki