Title:
HIGH-SPEED METHYLATION METHOD
Document Type and Number:
Japanese Patent JP2015178456
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method which enables high-speed methylation of an spcarbon under a condition of a low-concentration [C] CHI condition applicable to [C] methylation.SOLUTION: A high-speed methylation method comprises cross-coupling, with methyl iodide, a boronic acid ester compound with the carbon at the allyl or benzyl position converted to a boronate ester, in an aprotic polar solvent, e.g. DMF, in the presence of a palladium complex of formula Pd[PRRR](at least one of substituent groups R, Rand Ris an alkyl group) and a base. The aprotic polar solvent preferably contains water. Pd[PRRR]is typically Pd[P(tert-CH)].
Inventors:
SUZUKI MASAAKI
IJUIN RYOSUKE
DOI HISASHI
FURUYAMA HIROKO
IJUIN RYOSUKE
DOI HISASHI
FURUYAMA HIROKO
Application Number:
JP2012159725A
Publication Date:
October 08, 2015
Filing Date:
July 18, 2012
Export Citation:
Assignee:
RIKAGAKU KENKYUSHO
UNIV GIFU
UNIV GIFU
International Classes:
C07C1/32; C07B59/00; C07C15/073
Attorney, Agent or Firm:
Aoyama Yo
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