Title:
HISTONE DEACETYLASE INHIBITORS
Document Type and Number:
Japanese Patent JP2018012718
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds having the activity to inhibit histone deacetylases (e.g., HDAC1, HDAC2, and HDAC3).SOLUTION: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt. [when n is 1, Z is R-X-Ar/Het; Ar/Het is pyrazolyl, thiazolyl, oxazolyl, imidazolyl or the like; Ris H, F, Cl, CF, CFCF, CHCFor the like; Ris H, F, or Cl].SELECTED DRAWING: None
Inventors:
VINCENT JACQUES
JAMES R RUSCHE
NORTON P PEET
SINGH JASBIR
JAMES R RUSCHE
NORTON P PEET
SINGH JASBIR
Application Number:
JP2017161679A
Publication Date:
January 25, 2018
Filing Date:
August 24, 2017
Export Citation:
Assignee:
BIOMARIN PHARM INC
International Classes:
C07D231/12; C07D233/64; C07D261/08; C07D263/32; C07D277/30; C07D401/06; C07D403/06; C07D471/04; C07D513/04
Domestic Patent References:
| JP2003514904A | 2003-04-22 | |||
| JP2005508905A | 2005-04-07 | |||
| JP2007530459A | 2007-11-01 | |||
| JP2008536926A | 2008-09-11 | |||
| JP2005508311A | 2005-03-31 | |||
| JP2005530748A | 2005-10-13 | |||
| JP2009536615A | 2009-10-15 | |||
| JP6250403B2 | 2017-12-20 | |||
| JP2006514998A | 2006-05-18 | |||
| JP2008534637A | 2008-08-28 |
Foreign References:
| WO2010028192A1 | 2010-03-11 | |||
| WO2012016081A2 | 2012-02-02 |
Other References:
VANNINI ALESSANDRO: "SUBSTRATE BINDING TO HISTONE DEACETYLASES AS SHOWN BY THE CRYSTAL STRUCTURE 以下備考", EMBO REPORTS, vol. V8 N9, JPN5014004781, 2007, pages 879 - 884, ISSN: 0003886338
Attorney, Agent or Firm:
Mizuno Yuuki