Title:
HIV-1-SPECIFIC RNA INTERFERENCE MOLECULE
Document Type and Number:
Japanese Patent JP2008306962
Kind Code:
A
Abstract:
To provide an RNA interference molecule having low off-target effects and exhibiting effective RNA interfering actions on HIV-1 (human immunodeficiency virus-1) which is a highly diverse virus.
All the partial sequences of 21 bases are formed on the basis of 495 kinds of genomic sequences of HIV-1 group M, and RNA interference molecules satisfying design conditions are selected according to an siRNA (small-interfering RNA) design guideline by Ui-Tei et al. to study the siRNA target cleavage assay and proliferation inhibitory effects on the HIV-1. Thereby, an effective RNA interference molecule can be constructed by using a preservation region at the maximum level as the target for the HIV-1.
Inventors:
TAKEBE YUTAKA
NAITO TAKEKI
SAIGO KAORU
TEI KUMIKO
NAITO TAKEKI
SAIGO KAORU
TEI KUMIKO
Application Number:
JP2007156767A
Publication Date:
December 25, 2008
Filing Date:
June 13, 2007
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND
International Classes:
C12N15/09; A61K31/7105; A61K48/00; A61P31/18; C12Q1/68
Other References:
JPN6012040519; 第２８回日本分子生物学会年会 講演要旨集 , 20051125, ｐ． ２２０
JPN6012040518; 第５３回日本ウイルス学会学術集会プログラム・抄録集 , 20051101, ｐ． １０４
JPN6012040518; 第５３回日本ウイルス学会学術集会プログラム・抄録集 , 20051101, ｐ． １０４
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Yuriko Shinobu
Takuya Osugi
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