Title:
抗DSC2抗体のエフェクター機能を用いて細胞を障害する方法
Document Type and Number:
Japanese Patent JP2008539693
Kind Code:
A
Abstract:
The present invention is based on the discovery that the cytoxicity of anti-desmocollin 2 (DSC2) antibodies can be used for treating various cancers including lung, colon, pancreatic, prostate, breast, gastric or liver cancers. Specifically, the present invention provides antibodies against DSC2 that have effector function. Furthermore, the present invention provides methods and pharmaceutical compositions that comprise anti-DSC2 antibody as an active ingredient for damaging DSC2-expressing cells via the effector function of the antibody.
Inventors:
Shuichi Nakatsuru
Taka Iwamoto
Emi Yoshikawa
Taka Iwamoto
Emi Yoshikawa
Application Number:
JP2007541570A
Publication Date:
November 20, 2008
Filing Date:
May 11, 2006
Export Citation:
Assignee:
OncoTherapy Science Co., Ltd.
International Classes:
C12N15/09; A61K31/7088; A61K39/395; A61K48/00; A61P35/00; A61P43/00; C07K7/06; C07K7/08; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08
Domestic Patent References:
| JP2005261201A | 2005-09-29 |
Foreign References:
| WO2004031413A2 | 2004-04-15 | |||
| WO2003084569A1 | 2003-10-16 | |||
| WO2004087757A2 | 2004-10-14 | |||
| US20050215770A1 | 2005-09-29 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue