Title:
骨密度の低下を伴う疾患の診断方法
Document Type and Number:
Japanese Patent JP7379468
Kind Code:
B2
Abstract:
The invention relates to a method for diagnosing a disease that is accompanied by reduced bone density and/or calcium loss, comprising the following steps: a) determining isotope ratios or amount ratios of alkaline-earth metal portions in a sample of urine or blood or stool, b) thereby determining at least one sample value, and c) comparing the at least one sample value with a threshold value, the threshold value being selected independently of one or more factors determined by the individual patient. The invention further relates to a test kit for use in carrying out the method.
Inventors:
eisenhower anton
Application Number:
JP2021510331A
Publication Date:
November 14, 2023
Filing Date:
August 28, 2019
Export Citation:
Assignee:
GEOMAR Helmholtz-Zentrum fuer Ozeanforschung Kiel
International Classes:
G01N33/84; G01N33/49; G01N33/493
Domestic Patent References:
| JP7506719A | ||||
| JP2016003968A |
Foreign References:
| US20120225486 | ||||
| US20140273248 | ||||
| CN104698063A | ||||
| US20100193681 | ||||
| US20130115650 |
Other References:
GORDON, G. W. et al.,Predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition,Leukemia,2014年,Vol.28,pp.2112-2115
GORDON, G. W. et al.,Calcium Isotopic Composition and Its Association With Multiple Myeloma Disease Activity,blood,2013年11月15日,Vol.122, No.21,pp.1-3
TANAKA, Y. et al.,Calcium isotope signature: new proxy for net change in bone volume for chronic kidney disease and diabetic rats,Metallomics,2017年12月,Vol.9, No.12,pp.1745-1755
上西一弘 ほか,ダブルアイソトープ法による閉経後女性のカルシウム吸収率の検討,Osteoporosis Japan,2011年,Vol.19, No.2,pp.112(240)-115(243)
GORDON, G. W. et al.,Calcium Isotopic Composition and Its Association With Multiple Myeloma Disease Activity,blood,2013年11月15日,Vol.122, No.21,pp.1-3
TANAKA, Y. et al.,Calcium isotope signature: new proxy for net change in bone volume for chronic kidney disease and diabetic rats,Metallomics,2017年12月,Vol.9, No.12,pp.1745-1755
上西一弘 ほか,ダブルアイソトープ法による閉経後女性のカルシウム吸収率の検討,Osteoporosis Japan,2011年,Vol.19, No.2,pp.112(240)-115(243)
Attorney, Agent or Firm:
Ono International Patent Office