Title:
How to evaluate advance of the condition of the neoplasm by the quantitative detection of DNA in blood
Document Type and Number:
Japanese Patent JP6100685
Kind Code:
B2
Abstract:
The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated. Provided is a method for assessing the progression of the clinical state of a malignant neoplasm in a subject who has been administered with a medicine for treating the malignant neoplasm, the method being characterized by comprising: (1) a step of determining the ratio of DNA molecules having an activation mutation that serves as an activation marker for the medicine to DNA molecules having a normal marker gene in DNA in the blood from the subject; (2) a step of determining the ratio of DNA molecules having a resistance mutation that serves as a resistance marker for the medicine to DNA molecules having a normal marker gene in the DNA in the blood from the subject; and (3) a step of comparing a value obtained in the step (2) with a value obtained in the step (1) to thereby assess whether or not the malignant neoplasm in the subject has acquired resistance to the treatment with the medicine.
Inventors:
Kikuya Kato
Fumio Imamura
Kazuya Taniguchi
Kumagai Toru
Junji Uchida
Kazumi Nishino
Fumio Imamura
Kazuya Taniguchi
Kumagai Toru
Junji Uchida
Kazumi Nishino
Application Number:
JP2013515184A
Publication Date:
March 22, 2017
Filing Date:
May 16, 2012
Export Citation:
Assignee:
Osaka Prefectural Hospital Organization
Dna chip research institute
Dna chip research institute
International Classes:
C12Q1/68
Other References:
JPN6012040017; Ｏｎｃｏｇｅｎｅ， ２００９， ２８ Ｓｕｐｐｌ． １， Ｓ２４-３１
JPN6013037479; Ｃａｎｃｅｒ Ｒｅｓ．， ２００６， ６６（１６）， ｐｐ．７８５４-７８５８
JPN6012040018; '西谷公良他５名、"ＢＥＡＭｉｎｇ技術を応用した非小細胞肺癌におけるＥＧＦＲ遺伝子Ｔ７９０Ｍ変異の検出"' 日本癌学会学術総会記事、２００９年、３２１頁、Ｐ-０７１３
JPN6012040019; Ｃｌｉｎ． Ｃｈｅｍ．， ２００９， ５５（４）， ｐｐ．７４８-７５６
JPN6012040020; Ｃｌｉｎ． Ｃｈｅｍ．， ２０１１ Ｍａｙ， ５７（５）， ｐｐ．７７０-７７３
JPN6012040021; Ｃｌｉｎ． Ｃａｎｃｅｒ Ｒｅｓ．， ２００９， １５（６）， ｐｐ．２０７６-２０８４
JPN6012040022; Ｎ． Ｅｎｇｌ． Ｊ． Ｍｅｄ．， ２０１０， ３６３（１８）， ｐｐ．１７３４-１７３９
JPN6012040023; Ｂｌｏｏｄ， ２００２， ９９（９）， ｐｐ．３４７２-３４７５
JPN6013037479; Ｃａｎｃｅｒ Ｒｅｓ．， ２００６， ６６（１６）， ｐｐ．７８５４-７８５８
JPN6012040018; '西谷公良他５名、"ＢＥＡＭｉｎｇ技術を応用した非小細胞肺癌におけるＥＧＦＲ遺伝子Ｔ７９０Ｍ変異の検出"' 日本癌学会学術総会記事、２００９年、３２１頁、Ｐ-０７１３
JPN6012040019; Ｃｌｉｎ． Ｃｈｅｍ．， ２００９， ５５（４）， ｐｐ．７４８-７５６
JPN6012040020; Ｃｌｉｎ． Ｃｈｅｍ．， ２０１１ Ｍａｙ， ５７（５）， ｐｐ．７７０-７７３
JPN6012040021; Ｃｌｉｎ． Ｃａｎｃｅｒ Ｒｅｓ．， ２００９， １５（６）， ｐｐ．２０７６-２０８４
JPN6012040022; Ｎ． Ｅｎｇｌ． Ｊ． Ｍｅｄ．， ２０１０， ３６３（１８）， ｐｐ．１７３４-１７３９
JPN6012040023; Ｂｌｏｏｄ， ２００２， ９９（９）， ｐｐ．３４７２-３４７５
Attorney, Agent or Firm:
Taro Yaguchi
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