Title:
TRPV1アンタゴニストである中枢神経系薬剤を作製する方法
Document Type and Number:
Japanese Patent JP2011515414
Kind Code:
A
Abstract:
The invention discloses a process of making compounds of formula (XXIV): and methods of making the compounds, which are VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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Inventors:
Rookin, Kirill A
Kotsky, Brian Jay
Yui, Sue
Wan, Ray
Hate, Anthony Earl
Kotsky, Brian Jay
Yui, Sue
Wan, Ray
Hate, Anthony Earl
Application Number:
JP2011500970A
Publication Date:
May 19, 2011
Filing Date:
March 20, 2009
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
C07D231/56; C07C211/27; C07C211/42; C07C275/24; C07C275/26; A61K31/416; A61P13/10; A61P25/04; A61P43/00; C07B61/00
Domestic Patent References:
| JP2007536266A | 2007-12-13 |
Foreign References:
| WO2007121339A2 | 2007-10-25 | |||
| WO2008024945A1 | 2008-02-28 | |||
| WO2007046747A1 | 2007-04-26 | |||
| WO2006109933A1 | 2006-10-19 | |||
| WO2002083648A1 | 2002-10-24 |
Other References:
JPN6013039895; ＤＡＩ，Ｙ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．５０, 2007, ｐ．１５８４-１５９７， Ｓ１-８
JPN6013039896; ＬＵＫＩＮ，Ｋ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７１, 2006, ｐ．８１６６-８１７２
JPN6013039898; ＰＥＴＲＥＮＫＯ，Ｎ．Ｉ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４９, 1990, ｐ．３５９-３６６
JPN6013039896; ＬＵＫＩＮ，Ｋ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．７１, 2006, ｐ．８１６６-８１７２
JPN6013039898; ＰＥＴＲＥＮＫＯ，Ｎ．Ｉ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４９, 1990, ｐ．３５９-３６６
Attorney, Agent or Firm:
Kawaguchi International Patent Office