血管拡張剤を必要としない冠血流予備量比を測定する方法

Japanese Patent JP6976011

B2

Provided is a method for measuring a fractional flow reserve without a vasodilator, including the following steps: measuring a pressure P1 at a coronary artery inlet by a blood pressure sensor; acquiring a two-dimensional vessel diameter and length of a blood vessel by an angiography image, and generating a three-dimensional blood vessel grid model and acquiring a three-dimensional vessel diameter and length of the blood vessel; measuring a time taken for blood flowing from a start point to an end point of a segment of the blood vessel and calculating a blood flow velocity V1 based on the time and the three-dimensional length of the blood vessel; calculating an aortic pressure P2 in a maximum hyperemia state; calculating a blood flow velocity V2 in the maximum hyperemia state; taking the blood flow velocity V2 as a velocity at the coronary artery inlet and the aortic pressure P2 as a pressure Pa at the coronary artery inlet, calculating a pressure drop ΔP from the coronary artery inlet to a distal end of a coronary stenosis, a mean intracoronary pressure Pd at the distal end of the stenosis Pd = Pa-ΔP; and, by the formula CAFFR = Pd/Pa, and calculating coronary angiography fractional flow reserve CAFFR based on the formula of CAFFR=Pd/Pa. The advantage of the disclosure is that the fractional flow reserve can be calculated by an angiography image, an aortic pressure and blood flow, without using the vasodilator.

Fu, Infei
Ryu, Kwanji
One, Jiyuan
Chan, Hailin
Fu, Yong
Goon, Yenchuin
Li, Jienpin
Lee, Tie Two
Yang, fan

JP2020542074A

December 01, 2021

June 13, 2018

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Sucho Rainmed Medical Technology Company Limited

A61B5/026; A61B5/0215; A61B5/027

JP2019524235A
JP2016511682A
JP2018535816A
JP2018533383A
JP2016135265A

Asahina Patent Office

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