Title:
組み換えタンパク質の産生プロファイルを修飾する方法
Document Type and Number:
Japanese Patent JP6749994
Kind Code:
B2
Abstract:
The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of a triazine dye or supplemented with an effective amount of a triazine dye, whereby production of said protein is increased relative to cells grown without said triazine dye or any other inducer.
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Inventors:
Anais Mule
David Bruhlmann
Martin jordan
Herve Brouli
Mathieu Tetra
David Bruhlmann
Martin jordan
Herve Brouli
Mathieu Tetra
Application Number:
JP2018502100A
Publication Date:
September 02, 2020
Filing Date:
July 07, 2016
Export Citation:
Assignee:
Ares Trading Society Anonym
International Classes:
C12P21/08; C07K16/18; C09B62/04; C12N5/07; C12N5/10
Domestic Patent References:
| JP2007500721A | ||||
| JP2012519700A | ||||
| JP2010511378A |
Foreign References:
| US20070077552 | ||||
| WO2014110440A1 | ||||
| WO2014151901A1 | ||||
| WO2001059069A1 |
Other References:
Sugai M et al,FEMS Microbiology Letters,1990年,67,175-178
Miller K J et al,Neuropharmacology,1998年,37(12),1579-1586
Noo Soo Kim et al,Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production,Biotechnology and Bioengineering,2000年,71(3),184-193
P.Hossler et al,Biotechnology Progress,2013年,29(4),1023-1033
F.M.Wurm,Nature Biotechnology,2004年,22,1393-1398
Miller K J et al,Neuropharmacology,1998年,37(12),1579-1586
Noo Soo Kim et al,Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production,Biotechnology and Bioengineering,2000年,71(3),184-193
P.Hossler et al,Biotechnology Progress,2013年,29(4),1023-1033
F.M.Wurm,Nature Biotechnology,2004年,22,1393-1398
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidena Tsuda