Title:
特定交叉反応性を高める抗原構造を得る方法
Document Type and Number:
Japanese Patent JP4099059
Kind Code:
B2
Abstract:
The present invention is related to a method for obtaining antigenic structures with high cross reactivity, able to enhance the immune response to peptidic antigens administered systemically and/or mucosally, as well as with the chemical structures obtained from this method, and with formulations obtained and their uses. The method described in the present invention enables the obtaining of new antigenic structures, starting from the selection and synthesis of dendrimers, which are coupled to carrier molecules. The resulting structures can be used adjuvated conveniently or in a formulation of various antigens. A synergistic effect can be found in the cross reactivity and immunogenicity. Furthermore, the formulations may contain stabilizers and preserves. The antigenic structures of the present invention can be used in the pharmaceutical industry as vaccine formulations to prevent or to treat diseases in humans and animals, as well as in the development of diagnostic systems.
More Like This:
Inventors:
Cruz Le Condo, Lewis, Javier
Aguilar Rubid, Julio, Sisal
Iglesias Perez, Enrique
Reyes Acosta, Oswald
Galei Perez, Hilda, Elisa
Muzio Gonzales, Verena, Lucilla
Gillen Nieto, Gerard, Enrique
Dual tecano, carlos
Penton Arias, Eduard
Aguilar Rubid, Julio, Sisal
Iglesias Perez, Enrique
Reyes Acosta, Oswald
Galei Perez, Hilda, Elisa
Muzio Gonzales, Verena, Lucilla
Gillen Nieto, Gerard, Enrique
Dual tecano, carlos
Penton Arias, Eduard
Application Number:
JP2002538969A
Publication Date:
June 11, 2008
Filing Date:
November 01, 2001
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
C07K19/00; C12P21/02; A61K39/00; A61K39/12; A61K39/21; A61K39/29; A61K39/385; A61K47/48; A61P31/00; A61P31/18; A61P35/00; A61P37/00; C07K7/08; C07K14/00; C07K14/16; C07K14/18; C07K14/22; C07K14/575; C08G83/00; A61K
Domestic Patent References:
| JP11509172A | ||||
| JP63501876A |
Foreign References:
| WO1998039032A1 |
Other References:
J. Peptide Sci.,2000年 5月,6,p.217-224
J. Immunol. Methods,1996年,196 [1],p.17-32
Genet. Anal. : biomolecular engineering,1999年,15,p.149-153
Science,1991年,254,p.285-288
J. Immunol. Methods,1996年,196 [1],p.17-32
Genet. Anal. : biomolecular engineering,1999年,15,p.149-153
Science,1991年,254,p.285-288
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Previous Patent: ヒトサイトメガロウィルスＰＰ１５０の免疫反応性ペプチドＣＴＬエピト...
Next Patent: ガス流により回転支持され回転駆動される基板保持器を備えたＣＶＤ反応...
Next Patent: ガス流により回転支持され回転駆動される基板保持器を備えたＣＶＤ反応...