A method of reversing the effects of the tumor microenvironment using chimeric cytokine receptors

Title:

A method of reversing the effects of the tumor microenvironment using chimeric cytokine receptors

Document Type and Number:

Japanese Patent JP6297129

Kind Code:

B2

Abstract:

Disclosed are compositions and methods related to rendering ineffective Thl T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Thl immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IE 10, IE 13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.

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Inventors:

Lean, Anne, Marie
Vera, Juan, F.

Application Number:

JP2016246100A

Publication Date:

March 20, 2018

Filing Date:

December 20, 2016

Export Citation:

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Assignee:

BAYLOR COLLEGE OF MEDICINE

International Classes:

C12N5/10; A61K35/17; A61K39/00; A61P35/00; C12N15/09

Domestic Patent References:

JP2011045375A
JP2004315381A
JP2009500346A
JP2004531237A

Attorney, Agent or Firm:

Patent Business Corporation Unias International Patent Office

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