癌細胞を標的とする遺伝子の伝達方法

Title:

癌細胞を標的とする遺伝子の伝達方法

Document Type and Number:

Japanese Patent JP4459964

Kind Code:

B2

Abstract:

The inventive chimeric ligand in the form of a fusion polypeptide of a single-chain antibody specific for Tag-72 surface antigen and GaLV envelope glycoprotein shows high transduction efficiency to cancer cells, specifically infects target cells and efficiently delivers a therapeutic gene. Accordingly, the inventive chimeric ligand can be effectively used for gene therapy to inhibit tumor growth and metastasis.

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Inventors:

Kim Young Seo
Seo Insop
Lee Young Kwan
Kim Jong Pill
Kang Monkyun
Hong Hyo Jung

Application Number:

JP2006539363A

Publication Date:

April 28, 2010

Filing Date:

March 15, 2004

Export Citation:

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Assignee:

INJE UNIVERSITY

International Classes:

C07K19/00; C12N15/09; A61K38/00; A61P35/00; C07K14/15; C07K16/30; C12N5/10; C12N7/00; C12N15/867

Other References:

Dingli D. et al., Genetic targeting of retroviral vectors, Mar. 2003,p.267-291
Int. J. Cancer, 2001, Vol.94, p.717-726
Virology, 2000, Vol.269, p.7-17
The Journal of Gene Medicine, 1999, Vol.1, p.300-311

Attorney, Agent or Firm:

Kyousei Tamura
Nagatoshi Shinagawa

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