Title:
HUMAN PAPILLOMA VIRUS INHIBITION BY HAIRPIN RIBOZYME
Document Type and Number:
Japanese Patent JP2006149387
Kind Code:
A
Abstract:
To provide a hairpin ribozyme usable in cleaving an RNA transcribed from a human papilloma virus (HPV)-derived gene in the RNA's E6 gene domain.
The hairpin ribozyme including a synthetic ribozyme, i.e. a hairpin portion, binding sites for binding to HPV after viral base 419 or 434, respectively, and cleavage sites for cleaving HPV virus, is provided. A method for detecting virus in tissues based on PCR amplification is also provided.
Inventors:
HAMPEL ARNOLD
DIPAOLO JOSEPH
SIWKOWSKI ANDREW
DIPAOLO JOSEPH
SIWKOWSKI ANDREW
Application Number:
JP2005346709A
Publication Date:
June 15, 2006
Filing Date:
November 30, 2005
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
UNIV NORTHERN ILLINOIS (US)
UNIV NORTHERN ILLINOIS (US)
International Classes:
A61K31/282; C12N15/09; A61K31/70; A61K35/12; A61K38/43; A61K45/00; A61K48/00; A61P31/12; A61P35/00; C12N5/00; C12N5/10; C12N9/00; C12N15/113; C12Q1/68; C12Q1/683; C12Q1/70; A61K38/00; C12R1/91
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata
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