Title:
ヒト化抗CD11a抗体
Document Type and Number:
Japanese Patent JP4309383
Kind Code:
B2
Abstract:
Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1nM in the mixed lymphocyte response assay.
Inventors:
Paula M Jardeu
Leonard G. Presta
Leonard G. Presta
Application Number:
JP2005224609A
Publication Date:
August 05, 2009
Filing Date:
August 02, 2005
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
A61K39/395; G01N33/53; A61P1/00; A61P11/06; A61P17/00; A61P19/00; A61P29/00; A61P37/06; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08; A61K38/00
Other References:
HILDRETH,J.E. et al,A human lymphocyte-associated antigen involved in cell-mediated lympholysis,Eur J Immunol,1983年,Vol.13, No.3,p.202-8
Edwards CP,,Identification of amino acids in the CD11a I-domain important for binding of the leukocyte function-associated antigen-1 (LFA-1) to intercellular adhesion molecule-1 (ICAM-1),J Biol Chem,1995年,Vol.270, No.21,p.12635-40
Edwards CP,,Identification of amino acids in the CD11a I-domain important for binding of the leukocyte function-associated antigen-1 (LFA-1) to intercellular adhesion molecule-1 (ICAM-1),J Biol Chem,1995年,Vol.270, No.21,p.12635-40
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro