Title:
コレステロール管理およびそれに関連した使用に供するヒドロキシル化合物および組成物
Document Type and Number:
Japanese Patent JP4931349
Kind Code:
B2
Abstract:
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics; such as hypocholesterolemic and hypoglycemic agents.
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Inventors:
Dashu, Jean-Louis, Henri
Onishiu, Daniela, Carmen
Onishiu, Daniela, Carmen
Application Number:
JP2004567452A
Publication Date:
May 16, 2012
Filing Date:
December 23, 2003
Export Citation:
Assignee:
Esperion Therapeutics, Incorporated
International Classes:
C07C31/22; A61K31/047; A61K31/121; A61K31/194; A61K31/20; A61K31/23; A61K31/235; A61K31/255; A61K31/275; A61K31/337; A61K31/341; A61K31/351; A61K31/41; A61K31/4178; A61K31/422; A61K31/4365; A61K31/661; A61K31/664; A61P1/04; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/12; A61P13/12; A61P15/10; A61P17/00; A61P19/02; A61P19/06; A61P21/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07C31/20; C07C31/24; C07C59/11; C07C59/245; C07C59/285; C07C59/29; C07C59/46; C07C59/48; C07C59/54; C07C62/02; C07C62/06; C07C65/17; C07C69/675; C07C69/757; C07D213/65; C07D213/80; C07D309/10; C07D309/12; C07D405/12; C07F9/09; C07F9/117; C07F9/24; C07F9/44
Domestic Patent References:
| JPS51125043A | 1976-11-01 | |||
| JPH02282339A | 1990-11-19 |
Foreign References:
| US4066692A | 1978-01-03 | |||
| US4518809A | 1985-05-21 |
Attorney, Agent or Firm:
Masahiro Nanjo
Makoto Shiraishi
Makoto Shiraishi