Title:
【発明の名称】アンドロゲン過剰状態治療用の4-アザステロイド
Document Type and Number:
Japanese Patent JPH11512434
Kind Code:
A
Abstract:
Compounds of structural Formula (I), and pharmacologically acceptable salts and esters thereof possess 5 alpha -reductase inhibitory activity. These compounds inhibit 5 alpha -reductase type 1 and type 2. The compounds of structural Formula (I) are useful in the systemic, including oral, and parenteral, including topical, treatment and prevention of hyperandrogenic conditions including prostatic carcinoma, benign prostatic hyperplasia, acne vulgaris, seborrhea, androgenic alopecia (also called androgenetic alopecia) which includes male- and female-pattern baldness, female hirsutism, and prostatitis. A class of compounds of the present invention are also potent anti-androgens. The present invention also relates to novel compositions containing such compounds, methods of their use and methods of their manufacture.
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Inventors:
Bakushi, Raman Kay
Sahoe, Somiya Pee
Tolman, Lithium El
Sahoe, Somiya Pee
Tolman, Lithium El
Application Number:
JP51206896A
Publication Date:
October 26, 1999
Filing Date:
September 11, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/58; A61K31/00; A61K31/435; A61P5/24; C07J43/00; C07J73/00; (IPC1-7): C07J43/00; A61K31/00; A61K31/58
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)