Title:
【発明の名称】炭酸ビス-トリクロロメチルを用いたアミノ酸のカップリング方法
Document Type and Number:
Japanese Patent JP2002520331
Kind Code:
A
Abstract:
A process is disclosed for using bis-(trichloromethyl)carbonate (triphosgene), diphosgene or phosgene as efficient and effective coupling reagents during coupling of carbohydrates to peptide chains. This process is particularly useful for the coupling to sterically hindered amino acid residues, or for other difficult couplings. The reagents can be used for the derivatization of peptides by formation of a bond between a free amine on a peptide and a carbohydrate.
Inventors:
Farb, Elisa
Yeseteckel, Tamar
Saritra, Joseph
Yeseteckel, Tamar
Saritra, Joseph
Application Number:
JP2000559127A
Publication Date:
July 09, 2002
Filing Date:
July 11, 1999
Export Citation:
Assignee:
Pepter, Limited
International Classes:
C07K1/04; C07K1/06; C07K1/08; C07K5/00; C07K5/103; C07K5/107; C07K1/10; C07K5/11; C07K7/06; C07K7/08; A61K38/00; (IPC1-7): C07K1/10; C07K1/04; C07K1/06; C07K5/00; C07K7/06; C07K7/08
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)