Title:
【発明の名称】抗癌剤としてのアントラセン誘導体
Document Type and Number:
Japanese Patent JP2002518367
Kind Code:
A
Abstract:
A compound is provided having the formula: wherein R<1 >and R<2 >are independently hydrogen, hydroxy, alkoxy or acyloxy R<3 >and R<4 >are independently oxo, hydroxy or hydrogen; one of R<5 >or R<6 >is -A-B and the other is hydrogen, hydroxy, alkoxy, acyloxy, a group -A-B or a group -amino-R<7>-O-Y; the or each A is independently a spacer group having the formula -amino-R<7>-O- which is bonded to the anthracene ring via the amino group nitrogen and to B via the -O- atom R<7 >is a divalent organic radical; B is an amino acid residue, a peptide group, or isostere thereof; and Y is hydrogen or a capping group, or a physiologically acceptable derivative thereof. The compounds primarily have utility against cancers, but also have use against viruses and parasites having topoisomerases.
Inventors:
Mincher, david john
Turnbull, Agnes
Turnbull, Agnes
Application Number:
JP2000554693A
Publication Date:
June 25, 2002
Filing Date:
June 16, 1999
Export Citation:
Assignee:
Beati G International Limited
International Classes:
A61K31/136; A61K31/223; A61K31/401; A61K31/403; A61K31/404; A61K31/451; A61K31/495; A61P35/00; C07C221/00; C07C225/34; C07C227/18; C07C229/08; C07C229/12; C07C229/26; C07C229/36; C07C271/20; C07C271/22; C07D207/08; C07D295/10; C07D207/16; C07D209/20; C07D211/46; C07D295/116; C07K5/06; C07K5/062; A61K38/00; (IPC1-7): C07C225/34; A61K31/136; A61K31/223; A61K31/401; A61K31/451; A61K31/495; A61P35/00; C07C221/00; C07C227/18; C07C229/08; C07C271/20; C07C271/22; C07D207/08; C07D207/16; C07D209/20; C07D211/46; C07D295/10; C07K5/06
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)