Title:
【発明の名称】色原性ジベンゾキサゼピノン及びジベンゾチアゼピノン酵素基質
Document Type and Number:
Japanese Patent JP3072350
Kind Code:
B2
Abstract:
Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.
More Like This:
Inventors:
Paul F. Collie
Application Number:
JP15007290A
Publication Date:
July 31, 2000
Filing Date:
June 11, 1990
Export Citation:
Assignee:
Bayer Corporation
International Classes:
G01N33/535; C07D267/18; C07D281/14; C07F9/6527; C07F9/6536; C07H17/00; C07K14/00; C09B53/02; C12Q1/34; C12Q1/37; C12Q1/42; C12Q1/44; G01N33/52; G01N33/53; (IPC1-7): C07D267/18; C07D281/14; C07F9/6527; C07F9/6536; C07H17/00; C09B53/02; G01N33/52; G01N33/53
Domestic Patent References:
| JP60218397A |
Other References:
Ａｎａｌｙｔｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．１４４（１９８５），ｐ．１９３−１９８
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)