Title:
【発明の名称】CCR2遺伝子のミスセンス対立遺伝子によるAIDSへの進行の遅延
Document Type and Number:
Japanese Patent JP2001514886
Kind Code:
A
Abstract:
The present invention relates to a CCR2 deletion mutant, designated "CCR2-64I." CCR2 is a C-C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered that the presence of the CCR2-64I allele correlates with a postponement of AIDS outcomes, and that infected individuals who have the CCR2-64I allele are at a reduced risk for progression from HIV-1 infection to the development of clinical AIDS and death. Isolated nucleic acid molecule encoding CCR2-64I and the establishment of cell lines that express CCR2-64I provides valuable tools for continuing research on HIV infection. Diagnostic methods for analysis of the allelic frequency of CCR2 wild-type and 64I genes are provided. In addition, antibodies which bind to CCR2-64I, CCR2-64I variants, and CCR2 binding agents represent potential anti-HIV agents.
Inventors:
Dean, Michael
O'Brien, Stephen Jay.
Smith, michael
Carrington, mary
O'Brien, Stephen Jay.
Smith, michael
Carrington, mary
Application Number:
JP2000509826A
Publication Date:
September 18, 2001
Filing Date:
August 10, 1998
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
G01N33/53; A61K31/711; A61K38/00; A61K39/395; A61K48/00; A61P11/00; A61P11/06; A61P19/02; A61P29/00; A61P31/18; A61P37/04; A61P43/00; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/12; C12P21/08; C12Q1/68; C12Q1/6883; C12Q1/70; (IPC1-7): C12N15/09; A61K31/711; A61K38/00; A61K39/395; A61K48/00; A61P11/00; A61P11/06; A61P19/02; A61P29/00; A61P31/18; A61P37/04; A61P43/00; C07K14/715; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Shusaku Yamamoto