Title:
【発明の名称】分泌通路を通る不適当に折り畳まれたタンパク質のコンダクタンス
Document Type and Number:
Japanese Patent JP2002528412
Kind Code:
A
Abstract:
This invention provides the methodology and agents for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention of proteins. Thus, the methods and agents of the present invention provide for the release of normally retained proteins from the endoplasmic reticulum. The present invention is particuarly useful for treating any disease or clinical condition which is at least partly the result of endoplasmic reticulum-associated retention or degradation of mis-assembled or mis-folded proteins.
Inventors:
Michael Jay Caplan
Marie E. Egan
Marie E. Egan
Application Number:
JP2000578001A
Publication Date:
September 03, 2002
Filing Date:
October 27, 1999
Export Citation:
Assignee:
Yale University
International Classes:
A61K9/12; A61K31/00; A61K31/02; A61K31/047; A61K31/05; A61K31/122; A61K31/343; A61K31/365; A61K31/40; A61K31/407; A61K31/55; A61K31/713; A61K45/00; A61K48/00; A61P3/06; A61P3/10; A61P11/00; A61P13/00; A61P31/12; A61P35/00; A61P43/00; C12Q1/48; G01N33/50; G01N33/68; (IPC1-7): A61K45/00; A61K9/12; A61K31/05; A61K31/343; A61K31/40; A61K31/713; A61K48/00; A61P3/06; A61P3/10; A61P11/00; A61P13/00; A61P31/12; A61P35/00; A61P43/00
Domestic Patent References:
| JPH09501922A | 1997-02-25 | |||
| JPH08500596A | 1996-01-23 | |||
| JPH10508575A | 1998-08-25 | |||
| JPH10501130A | 1998-02-03 |
Foreign References:
| WO1998037878A1 | 1998-09-03 | |||
| WO1993013768A1 | 1993-07-22 | |||
| WO1996036334A1 | 1996-11-21 |
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)