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Title:
【発明の名称】新規なスクシナート化合物、組成物、並びに使用及び調製方法
Document Type and Number:
Japanese Patent JP2003534239
Kind Code:
A
Abstract:
Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

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Inventors:
Jeffrey W. Jacobs
Rakesh Jean
Twizy knee
Dinesh Vi Patel
Tseng Yuan
Application Number:
JP2001545267A
Publication Date:
November 18, 2003
Filing Date:
December 13, 2000
Export Citation:
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Assignee:
Verge Core Incorporated
International Classes:
C07D217/26; A61K31/40; A61K31/401; A61K31/4025; A61K31/4178; A61K31/42; A61K31/427; A61K31/433; A61K31/435; A61K31/4439; A61K31/445; A61K31/454; A61K31/496; A61K31/497; A61K31/506; A61P31/00; A61P31/04; C07D207/06; C07D207/08; C07D207/09; C07D207/14; C07D207/16; C07D211/60; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; (IPC1-7): C07D207/08; A61K31/40; A61K31/401; A61K31/4025; A61K31/4178; A61K31/42; A61K31/427; A61K31/433; A61K31/435; A61K31/4439; A61K31/445; A61K31/454; A61K31/496; A61K31/497; A61K31/506; A61P31/04; C07D207/14; C07D207/16; C07D211/60; C07D217/26; C07D401/12; C07D403/12; C07D405/12; C07D413/12; C07D417/12
Domestic Patent References:
JPS57106658A1982-07-02
JPS6188884A1986-05-07
JPH093094A1997-01-07
Foreign References:
WO1999059568A11999-11-25
WO1999002510A11999-01-21
WO1995033731A11995-12-14
WO1998033788A11998-08-06
WO1995029892A11995-11-09
WO1999061431A11999-12-02
WO1999057097A21999-11-11
Attorney, Agent or Firm:
Masatake Shiga (7 outside)



 
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