Title:
【発明の名称】抗癌胎児抗原抗イディオタイプ抗体のヒト化と腫瘍ワクチンとしての使用及びターゲッティング用途のための使用
Document Type and Number:
Japanese Patent JP2000511403
Kind Code:
A
Abstract:
A humanized form of an anti-idiotype antibody to CEA, e.g., hWI2, has conserved immunoreactivity. The clinical benefits of anti-CEA antibodies are maximized by using the humanized anti-idiotype as a clearing agent for anti-CEA antibodies or antibody fragments. The humanized anti-idiotype also can be used as an immunogenic vaccine.
Inventors:
Lun, Shui On
Rothman, Michelle Jay
Hansen, Hans
Rothman, Michelle Jay
Hansen, Hans
Application Number:
JP53377697A
Publication Date:
September 05, 2000
Filing Date:
March 19, 1997
Export Citation:
Assignee:
Immunomedics, Inc.
International Classes:
C12N15/09; A61K31/00; A61K39/395; A61K49/00; A61P35/00; A61P37/00; A61P37/04; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; G01N33/53; G01N33/574; A61K39/00; (IPC1-7): C12N15/09; A61P35/00; A61P37/04; A61K39/395; A61K49/00; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53; G01N33/574
Attorney, Agent or Firm:
Nao Okuyama (3 others)