Title:
【発明の名称】D-酵素組成物およびそれらの使用方法
Document Type and Number:
Japanese Patent JPH08501207
Kind Code:
A
Abstract:
A ligated D-protein is disclosed represented by the formula: R-L-R' wherein: R and R' are D-peptides (amino acid residue sequences consisting essentially of D-amino acids), at least one of R and R' having a length of at least 50 amino acids and L represents a linkage unit for ligating R to R', L being selected from the group consisting of thiol ester and selenol ester linkage units. A method is also disclosed of identifying compounds that modulate receptor activity comprising: (a) contacting at least one compound from a chemical library with a D-receptor, and (b) determining said compound's ability to modulate said D-receptor's activity; wherein said compound is not known to inhibit said D-receptor activity prior to said contacting.
Inventors:
Kent, Stephen Brian Henry
Milton, Saskia Charlotte Florence
Milton, Raymond Cecil Delisle
Milton, Saskia Charlotte Florence
Milton, Raymond Cecil Delisle
Application Number:
JP50166094A
Publication Date:
February 13, 1996
Filing Date:
June 07, 1993
Export Citation:
Assignee:
The Scripps Research Institute
International Classes:
G01N33/50; A61K38/43; A61K38/44; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P19/02; A61P21/00; A61P29/00; A61P31/12; A61P35/00; A61P35/04; A61P37/00; C07K14/16; C12N9/00; C12N9/02; C12N9/50; C12N9/88; C12P41/00; C12Q1/25; C12Q1/26; C12Q1/34; C12Q1/37; C12Q1/48; C12Q1/527; G01N33/15; G01N33/573; G01N33/68; (IPC1-7): C12N9/00; C12N9/02; C12N9/50; C12N9/88; C12P41/00
Attorney, Agent or Firm:
Keiichiro Nishikyo (2 outside)