Title:
【発明の名称】合成N-結合グリココンジュゲートを製造するための方法
Document Type and Number:
Japanese Patent JPH11508564
Kind Code:
A
Abstract:
A transamination reaction of glycosyl-1-amine with a nucleophilic reagent containing an -NH2 or -NHNH2 group is used to prepared a broad spectrum of glycoconjugates by substitution of the 1-amino group. The substitution reaction does not adversely affect the ring structure of the sugar as does the prior art reductive amination reaction. Suitable nucleophilic reagents are nucleophiles having a chromophore group, a fluorophore group, a chemiluminescent group, a lipid, an amino acid or peptide moiety, biotin, a drug and a linker/spacer group and an affinity label. The ratio of glycosyl-1-amine to nucleophilic reagent is in the range of from about 1:1 to about 1:2 by weight.
More Like This:
Inventors:
Prasad, A, Buoy, Krysina
Richards, James Sea.
Richards, James Sea.
Application Number:
JP50466797A
Publication Date:
July 27, 1999
Filing Date:
June 28, 1996
Export Citation:
Assignee:
National Research Council of Canada
International Classes:
C07H5/04; C07H11/00; C07H15/04; C07H15/06; C07H15/12; C07H15/203; C07H15/207; C07H15/24; C07H15/26; C07K1/107; C07K9/00; C07K14/685; (IPC1-7): C07H5/04; C07H15/04; C07H15/06; C07H15/203; C07H15/207; C07H15/24; C07H15/26
Attorney, Agent or Firm:
Takashi Ishida (3 others)