Title:
【発明の名称】カルボキシル基保護基の除去方法
Document Type and Number:
Japanese Patent JP2847693
Kind Code:
B2
Abstract:
PURPOSE:To efficiently remove a protecting group by treating a beta-lactam compound having carboxyl protected with a substituted or unsubstituted allyl with a Pd catalyst in the presence of an allyl group scavenger. CONSTITUTION:A p-lactam compound-expressed by the formula (R is allyl; R<1> and R<2> are organic groups; X is CH2CH2, SCH2, OCH2, S, O, etc.; Y is S, O or single bond), etc., and having carboxyl protected with a substituted or unsubstituted allyl is treated in a water-containing organic solvent (e.g. ethanol- water) in the presence of an allyl group scavenger using a catalyst [e.g. tetrakis(triphenylphosphine)palladium(O)] under cooling to heating, e.g. at 30-100 deg.C to remove the substituted or unsubstituted allyl group. The [3-lactam compound is useful as a fungicide or its protodrug or synthetic intermediate thereof.
Inventors:
KONDO KAZUHIKO
HORIKAWA KOSHI
IWASAKI TAMEO
HORIKAWA KOSHI
IWASAKI TAMEO
Application Number:
JP13872293A
Publication Date:
January 20, 1999
Filing Date:
June 10, 1993
Export Citation:
Assignee:
TANABE SEIYAKU KK
International Classes:
C07B51/00; C07D463/00; C07D477/00; C07D501/04; C07D503/00; C07D513/04; (IPC1-7): C07D463/00; C07B51/00; C07D477/00; C07D501/04; C07D503/00; C07D513/04
Domestic Patent References:
| JP3130293A | ||||
| JP6261984A | ||||
| JP2290256A | ||||
| JP61286331A | ||||
| JP5594321A |
Other References:
【文献】国際公開92/2521(WO,A)
Attorney, Agent or Firm:
Shigeo Minoura