【発明の名称】一種以上の側鎖キレート基によるポリアザ大員環の合成

Title:

【発明の名称】一種以上の側鎖キレート基によるポリアザ大員環の合成

Document Type and Number:

Japanese Patent JPH07502994

Kind Code:

A

Abstract:

The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic acid derivatives, together with monomethylenephosphonate and monomethylenephosphinate derivatives of [12]aneN4, [12]aneN3 and [9]aneN3, make these types of ligands easily available by a synthetic pathway that avoids the use of protective groups. The invention thus comprises a variety of compounds, methods and uses characterized by relatively high synthetic yields of polyazamacrocyclic ligands exhibiting a wide and predictable choice of metal ion binding constants water and lipid solubilities by reason of their substituent pendent groups.

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Inventors:

Shelley, A. Dean
Van Westlenen, Jerun

Application Number:

JP51089093A

Publication Date:

March 30, 1995

Filing Date:

October 27, 1992

Export Citation:

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Assignee:

UNIV TEXAS (US)

International Classes:

A61K49/00; A61K49/06; A61K51/04; C07D257/00; C07D255/02; C07D257/02; C07D259/00; C07F5/00; C07F9/6515; C07F9/6524; G01N24/00; (IPC1-7): C07D257/00; A61K49/00; C07F9/6524

Attorney, Agent or Firm:

Nao Okuyama (2 outside)

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