Title:
【発明の名称】再狭窄および関連障害を治療するための酸化窒素放出ポリマーの使用
Document Type and Number:
Japanese Patent JPH10502905
Kind Code:
A
Abstract:
Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N2O2- functional group a compound comprising a nitric oxide-releasing N2O2- functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized.
Inventors:
Kiefer, Larry Kay.
Hassel, Thomas Sui.
Hassel, Thomas Sui.
Application Number:
JP52410395A
Publication Date:
March 17, 1998
Filing Date:
March 09, 1995
Export Citation:
Assignee:
US HEALTH (US)
COMEDICUS INC (US)
COMEDICUS INC (US)
International Classes:
A61K9/00; A61K31/44; A61K31/445; A61K31/495; A61K31/655; A61K31/785; A61K38/00; A61K47/48; A61P9/08; C07D295/22; C08F8/30; C07D295/12; (IPC1-7): A61K31/655; A61K9/00; A61K31/44; A61K31/445; A61K31/495; A61K31/785; A61K38/00; A61K47/48; C07D295/12; C07D295/22
Attorney, Agent or Firm:
Takashima Hajime